A research group led by Dr Kosuke Fujita of Osaka University has discovered that a plant-based polyphenol, promotes the
migration of Mesenchymal Stem Cells (MSCs) in blood circulation and accumulates
them in damaged tissues to improve wound healing. The researchers had previously
found that ethanol extracts of Mallotus philippinensis bark
promoted migrationof mesenchymal stem cells and improved wound healing in a
mouse model. In the present study, the researchers
analyzed the effects of cinnamtannin B-1 on MSC migration in vivo and
demonstrated that it mobilized the MSCs from the bone marrow to the blood from
where they moved to accumulate at the wound site. It is cinnamtannin
B-1, or vegetable-based polyphenol that promotes the migration of Mesenchymal
Stem Cells. MSCs were released from bone
marrow to the blood in cinnamtannin B-1-administered mice. Cinnamtannin B-1 enhanced wound healing.
The researchers say that these results will
be used for stem cell treatments for cutaneous disorders associated with
various damage and lesions.
Details appear in the latest issue of journal
PLOS ONE
No comments:
Post a Comment