1 Tahrcountry Musings: Environmental Toxicants can manifest for generations

Thursday, March 08, 2012

Environmental Toxicants can manifest for generations

Latest research on environmental toxicants indicates that that a variety of environmental toxicants can have negative effects for generations.

 The researchers found that even though the animal’s DNA sequence remains unchanged, the deleterious effects manifests clearly on the epigenetic effect. Jet fuel, dioxin, plastics and the pesticides DEET and permethrin have been shown to be causative agents of epigenetic disease across generations.

 The plastics, dioxin and jet fuel were found to promote early-onset female puberty transgenerationally.  Spermatogenic cell apoptosis was affected transgenerationally.

 Exposure-specific epigenetic biomarkers were identified. The researchers say this  may allow for the assessment of ancestral environmental exposures associated with adult onset disease.

Journal Reference:
Mohan Manikkam, Carlos Guerrero-Bosagna, Rebecca Tracey, Md. M. Haque, Michael K. Skinner.Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures. PLoS ONE, 2012; 7 (2): e31901 DOI:10.1371/journal.pone.0031901

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