Latest research on environmental toxicants indicates
that that a variety of environmental toxicants can have negative effects for
generations.
The researchers
found that even though the animal’s DNA sequence remains unchanged, the
deleterious effects manifests clearly on the epigenetic effect. Jet fuel,
dioxin, plastics and the pesticides DEET and permethrin have been shown to be
causative agents of epigenetic disease across generations.
The plastics,
dioxin and jet fuel were found to promote early-onset female puberty
transgenerationally. Spermatogenic cell
apoptosis was affected transgenerationally.
Exposure-specific epigenetic
biomarkers were identified. The researchers say this may allow for the assessment of ancestral
environmental exposures associated with adult onset disease.
Journal
Reference:
Mohan Manikkam, Carlos Guerrero-Bosagna, Rebecca
Tracey, Md. M. Haque, Michael K. Skinner.Transgenerational Actions of
Environmental Compounds on Reproductive Disease and Identification of
Epigenetic Biomarkers of Ancestral Exposures. PLoS ONE, 2012; 7 (2): e31901
DOI:10.1371/journal.pone.0031901
No comments:
Post a Comment